REGISTRATION REQUEST and ABSTRACT SUBMISSION DEADLINE: JULY 1, 2022
To attend the conferences Jacques Monod, an abstract submission is mandatory,
Registrations request without abstract submission will not be processed, except in specific
cases (i. g. for Publishers : please contact chairperson).
Chairperson: Ellen Nollen
European Research Institute for the Biology of Aging, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
Phone: +31 6 52724881
Email: e.a.a.nollen@umcg.nl
Vice-chairperson: Ronald Melki
Laboratory of Neurodegenerative Diseases, CNRS, Institut Francois Jacob (MIRCen), CEA, 18 Route du Panorama, 92265 Fontenay-Aux-Roses cedex, France
Phone: +33 (0)1 46 54 93 78
Email: ronald.melki@cnrs.fr
Cells and organisms maintain protein homeostasis in several cooperating ways, which include protein folding, degradation, and sequestration. During aging, the capacity to maintain protein homeostasis declines, which leads to the accumulation of aggregation-prone proteins. These aggregation-prone proteins can accelerate aging and cause age-related diseases like Parkinson’s disease, tauopathies, Alzheimer’s, and Amyotrophic Lateral Sclerosis. How they do so is still not fully understood. Understanding the underlying mechanisms will be important for the development of therapeutic strategies. Recent groundbreaking discoveries have revealed new aspects of protein homeostatic and pathological mechanisms. These include the phenomena of protein phase transitions in membrane-less organelles and the existence of amyloid polymorphisms that are associated with protein toxicity. These phenomena are shared by a range of stress and age-related conditions. This Jacques Monod meeting will highlight these phenomenon, including the biological mechanisms and structural features involved. New findings will be presented by scientists that pioneered the research in these areas. Regulation of both physiological and disease-related transitions will be addressed as well as perspectives on biomedical applications.
The meeting will bring together leading experts in the fields of structural biology, cell biology, physiology and medical biology. It aims to foster exchange of knowledge across these fields and to stimulate interdisciplinary collaboration to further advance the filed.