Protein phase transitions in ageing and age-related diseases: from atomic resolution to cellular solutions

 

REGISTRATION REQUEST and ABSTRACT SUBMISSION DEADLINE: JULY 1, 2022

 

 

To attend the conferences Jacques Monod, an abstract submission is mandatory,

Registrations request without abstract submission will not be processed, except in specific

cases (i. g. for Publishers : please contact chairperson).

 

Chairperson: Ellen Nollen

European Research Institute for the Biology of Aging, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands

Phone: +31 6 52724881

Email: e.a.a.nollen@umcg.nl

 

Vice-chairperson: Ronald Melki

Laboratory of Neurodegenerative Diseases, CNRS, Institut Francois Jacob (MIRCen), CEA, 18 Route du Panorama, 92265 Fontenay-Aux-Roses cedex, France

Phone: +33 (0)1 46 54 93 78

Email: ronald.melki@cnrs.fr

 

Cells and organisms maintain protein homeostasis in several cooperating ways, which include protein folding, degradation, and sequestration. During aging, the capacity to maintain protein homeostasis declines, which leads to the accumulation of aggregation-prone proteins. These aggregation-prone proteins can accelerate aging and cause age-related diseases like Parkinson’s disease, tauopathies, Alzheimer’s, and Amyotrophic Lateral Sclerosis. How they do so is still not fully understood. Understanding the underlying mechanisms will be important for the development of therapeutic strategies. Recent groundbreaking discoveries have revealed new aspects of protein homeostatic and pathological mechanisms. These include the phenomena of protein phase transitions in membrane-less organelles and the existence of amyloid polymorphisms that are associated with protein toxicity. These phenomena are shared by a range of stress and age-related conditions. This Jacques Monod meeting will highlight these phenomenon, including the biological mechanisms and structural features involved. New findings will be presented by scientists that pioneered the research in these areas. Regulation of both physiological and disease-related transitions will be addressed as well as perspectives on biomedical applications.

The meeting will bring together leading experts in the fields of structural biology, cell biology, physiology and medical biology. It aims to foster exchange of knowledge across these fields and to stimulate interdisciplinary collaboration to further advance the filed.

 

Applications submission

Registration fee (including board and lodging)

470 € for PhD students
760 € for other participants

Application for registration   details here :
The total number of participants is limited to 115 and all participants are expected to attend for the whole duration of the conference. Selection is made on the basis of the affinity of potential participants with the topics of the conference. Scientists and PhD Students interested in the meeting should deposit on line :

- their curriculum vitae
- the proof of their student status
- the list of their main publications for the 3 last years
- the abstract of their presentation:

The abstract must respect the following template: TemplateResumeFile
- First line: title
- Second line: list of authors. Presenting author underlined
- Third line: author's addresses
- Fourth line: e-mail of the presenting author
Abstracts should be no longer than an A4 page and preferably be submitted in Times New Roman, font size 10 pts. No figures. ".docx" file format.

After deadline, the organizers will select the participants. Except in some particular cases approved by the Chairperson, it is recommended that all selected participants present their work during the conference, either in poster form or by a brief in- session talk. The organizers choose the form in which the presentations are made. No payment will be sent with application. Information on how and when to pay will be mailed in due time to those selected.

 

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